A KRAP(y) job: Defining the localization of active IP3R

Vikas Arige; David I Yule

doi:10.1016/j.ceca.2021.102470

A KRAP(y) job: Defining the localization of active IP₃R

Cell Calcium. 2021 Dec:100:102470. doi: 10.1016/j.ceca.2021.102470. Epub 2021 Sep 9.

Authors

Vikas Arige¹, David I Yule²

Affiliations

¹ Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, 14642, United States.
² Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, 14642, United States. Electronic address: david_yule@urmc.rochester.edu.

PMID: 34583188
DOI: 10.1016/j.ceca.2021.102470

Abstract

A recent publication documented an exciting role for KRAP in tethering/immobilizing IP₃Rs to actin. This interaction "licenses" IP₃R activity as disrupting the partnership markedly diminishes Ca²⁺ puffs and global signals. These findings highlight a unique mechanism for regulating IP₃R activity.

Keywords: Actin; Ca(2+) puffs; Inositol 1,4,5-trisphosphate receptors; KRas-induced actin interacting protein; TIRF microscopy.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Actins*
Calcium* / metabolism
Inositol 1,4,5-Trisphosphate Receptors

Substances

Actins
Inositol 1,4,5-Trisphosphate Receptors
Calcium