COVID-19 patients and Dementia: Frontal cortex transcriptomic data

Maria Garofalo; Stella Gagliardi; Susanna Zucca; Cecilia Pandini; Francesca Dragoni; Daisy Sproviero; Orietta Pansarasa; Tino Emanuele Poloni; Valentina Medici; Annalisa Davin; Silvia Damiana Visonà; Matteo Moretti; Antonio Guaita; Mauro Ceroni; Livio Tronconi; Cristina Cereda

doi:10.1016/j.dib.2021.107432

COVID-19 patients and Dementia: Frontal cortex transcriptomic data

Data Brief. 2021 Oct:38:107432. doi: 10.1016/j.dib.2021.107432. Epub 2021 Sep 29.

Authors

Maria Garofalo^{1

2}, Stella Gagliardi¹, Susanna Zucca³, Cecilia Pandini¹, Francesca Dragoni^{1

2}, Daisy Sproviero¹, Orietta Pansarasa¹, Tino Emanuele Poloni⁴, Valentina Medici⁴, Annalisa Davin⁴, Silvia Damiana Visonà⁵, Matteo Moretti⁵, Antonio Guaita⁴, Mauro Ceroni^{6

7}, Livio Tronconi^{5

8}, Cristina Cereda¹

Affiliations

¹ Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy.
² Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
³ EnGenome SRL, Pavia 27100, Italy.
⁴ Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy.
⁵ Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences "A. Fornari", University of Pavia, Pavia, Italy.
⁶ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
⁷ Department of General Neurology, IRCCS Mondino Foundation, Pavia, Italy.
⁸ U.O. Medicina Legale, IRCCS Mondino Foundation, Pavia, Italy.

Abstract

Since the association of SARS-Cov-2 infection with Nervous System (NS) manifestations, we performed RNA-sequencing analysis in Frontal Cortex of COVID-19 positive or negative individuals and affected or not by Dementia individuals. We examined gene expression differences in individuals with COVID-19 and Dementia compared to Dementia only patients by collecting transcript counts in each sample and performing Differential Expression analysis. We found eleven genes satisfying our significance criteria, all of them being protein coding genes. These data are suitable for integration with supplemental samples and for analysis according to different individuals' classification. Also, differential expression evaluation may be implemented with other scientific purposes, such as research of unannotated genes, mRNA splicing and genes isoforms. The analysis of Differential Expressed genes in COVID-19 positive patients compared to non-COVID-19 patients is published in: S. Gagliardi, E.T. Poloni, C. Pandini, M. Garofalo, F. Dragoni, V. Medici, A. Davin, S.D. Visonà, M. Moretti, D. Sproviero, O. Pansarasa, A. Guaita, M. Ceroni, L. Tronconi, C. Cereda, Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients., Brain. Behav. Immun. (2021). https://doi.org/10.1016/j.bbi.2021.05.012.

Keywords: Brain; Gene expression; SARS-CoV-2; Transcriptomics.