Sensing spermidine through tongue-tied translation prevents too much of a good thing

Anthony J Michael

doi:10.1016/j.molcel.2021.09.014

Sensing spermidine through tongue-tied translation prevents too much of a good thing

Mol Cell. 2021 Oct 7;81(19):3882-3883. doi: 10.1016/j.molcel.2021.09.014.

Author

Anthony J Michael¹

Affiliation

¹ Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: anthony.michael@utsouthwestern.edu.

PMID: 34624213
DOI: 10.1016/j.molcel.2021.09.014

Abstract

Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine levels are sensed, and demonstrate that excess spermidine competitively inhibits eIF5a function, resulting in decreased spermidine uptake.

MeSH terms

Peptide Initiation Factors*
Saccharomyces cerevisiae
Spermidine*
Tongue

Substances

Peptide Initiation Factors
Spermidine