All eyes on a phosphatase in glioma stem cells

Robert A Lindquist; William A Weiss

doi:10.1084/jem.20211605

All eyes on a phosphatase in glioma stem cells

J Exp Med. 2021 Nov 1;218(11):e20211605. doi: 10.1084/jem.20211605. Epub 2021 Oct 12.

Authors

Robert A Lindquist^{1

2

3}, William A Weiss^{2

3

4

5}

Affiliations

¹ Division of Pediatric Hematology/Oncology, University of California, San Francisco, San Francisco, CA.
² Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
³ Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
⁴ Departments of Neurology and Neurosurgery, University of California, San Francisco, San Francisco, CA.
⁵ Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA.

Abstract

In this issue of JEM, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202669) identify a dependency of glioma stem cells on tyrosine phosphatase activity of EYA2 and a new role for this phosphatase at the centrosome, offering a new therapeutic approach to target mitotic activity.

Publication types

Comment

MeSH terms

Glioma* / genetics
Humans
Neoplastic Stem Cells
Phosphoric Monoester Hydrolases*

Substances

Phosphoric Monoester Hydrolases

Abstract

Publication types

MeSH terms

Substances

Grants and funding