Ragulator-Rag and ROS TORment gasdermin D pore formation

Venkat Giri Magupalli; Pietro Fontana; Hao Wu

doi:10.1016/j.it.2021.09.014

Ragulator-Rag and ROS TORment gasdermin D pore formation

Trends Immunol. 2021 Nov;42(11):948-950. doi: 10.1016/j.it.2021.09.014. Epub 2021 Oct 15.

Authors

Venkat Giri Magupalli¹, Pietro Fontana², Hao Wu³

Affiliations

¹ Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: venkat.magupalli@childrens.harvard.edu.
² Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
³ Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: wu@crystal.harvard.edu.

Abstract

Upon cleavage, the Gasdermin D (GSDMD) N-terminal fragment assembles into pores on the plasma membrane to orchestrate the lytic cell death known as pyroptosis. In a recent article, Evavold et al. showed that the Ragulator-Rag-mTORC1-ROS pathway controls the transition from cleavage and membrane localization to oligomerization and pore formation.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Humans
Inflammasomes / metabolism
Intracellular Signaling Peptides and Proteins* / metabolism
Neoplasm Proteins* / metabolism
Phosphate-Binding Proteins
Pyroptosis
Reactive Oxygen Species / metabolism

Substances

Inflammasomes
Intracellular Signaling Peptides and Proteins
Neoplasm Proteins
Phosphate-Binding Proteins
Reactive Oxygen Species

Abstract

Publication types

MeSH terms

Substances

Grants and funding