SUMO wrestling cancer stem cells

Qiang Liu; Jean C Y Wang; Stephanie Z Xie

doi:10.1016/j.chembiol.2021.10.001

SUMO wrestling cancer stem cells

Cell Chem Biol. 2021 Oct 21;28(10):1390-1392. doi: 10.1016/j.chembiol.2021.10.001.

Authors

Qiang Liu¹, Jean C Y Wang², Stephanie Z Xie³

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
² Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.
³ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: sxie@uhnresearch.ca.

PMID: 34678166
DOI: 10.1016/j.chembiol.2021.10.001

Abstract

Sumoylation is a reversible post-translational modification implicated in cancer. In this issue of Cell Chemical Biology, Benoit et al. describe an inhibitor of sumoylation that results in anti-proliferative effects in cancer stem cell models via the sumoylation enzyme SAE2.

Publication types

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MeSH terms

Humans
Neoplasms* / drug therapy
Neoplastic Stem Cells
Protein Processing, Post-Translational
Sumoylation*