Astrocytes, a Promising Opportunity to Control the Progress of Parkinson's Disease

Alberto Sanchez; Ingrid Morales; Clara Rodriguez-Sabate; Miguel Sole-Sabater; Manuel Rodriguez

doi:10.3390/biomedicines9101341

Astrocytes, a Promising Opportunity to Control the Progress of Parkinson's Disease

Biomedicines. 2021 Sep 28;9(10):1341. doi: 10.3390/biomedicines9101341.

Authors

Alberto Sanchez^{1

2}, Ingrid Morales^{1

2}, Clara Rodriguez-Sabate^{1

2

3}, Miguel Sole-Sabater⁴, Manuel Rodriguez^{1

2}

Affiliations

¹ Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, 38200 Tenerife, Spain.
² Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain.
³ Department of Psychiatry, Getafe University Hospital, 28905 Madrid, Spain.
⁴ Department of Neurology, La Candelaria University Hospital, 38010 Tenerife, Spain.

Abstract

At present, there is no efficient treatment to prevent the evolution of Parkinson's disease (PD). PD is generated by the concurrent activity of multiple factors, which is a serious obstacle for the development of etio-pathogenic treatments. Astrocytes may act on most factors involved in PD and the promotion of their neuroprotection activity may be particularly suitable to prevent the onset and progression of this basal ganglia (BG) disorder. The main causes proposed for PD, the ability of astrocytes to control these causes, and the procedures that can be used to promote the neuroprotective action of astrocytes will be commented upon, here.

Keywords: Parkinson’s disease; astrocyte; cell treatment; dopamine neuron.

Publication types

Review