Autophagy in Staphylococcus aureus Infection

Mengyao Wang; Ziyao Fan; Hongbing Han

doi:10.3389/fcimb.2021.750222

Autophagy in Staphylococcus aureus Infection

Front Cell Infect Microbiol. 2021 Oct 7:11:750222. doi: 10.3389/fcimb.2021.750222. eCollection 2021.

Authors

Mengyao Wang^{1

2

3}, Ziyao Fan⁴, Hongbing Han^{1

2

3}

Affiliations

¹ Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, China.
² National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
³ Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.
⁴ Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.

Abstract

Staphylococcus aureus is an invasive, facultative intracellular pathogen that can colonize niches in various host organisms, making it difficult for the host immune system to completely eliminate. Host autophagy is an intracellular clearance pathway involved in degrading S. aureus. Whereas the accessory gene regulatory system of S. aureus that controls virulence factors could resist the host immune defenses by evading and even utilizing autophagy. This article reviews the interaction between autophagy and S. aureus, providing insights on how to use these mechanisms to improve S. aureus infection control.

Keywords: Staphylococcus aureus; accessory gene regulatory system; autophagy; host-pathogen interactions; intracellular persistence.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy
Host-Pathogen Interactions
Humans
Staphylococcal Infections*
Staphylococcus aureus* / genetics
Virulence Factors / genetics

Substances

Virulence Factors