Di-anionic self-associating supramolecular amphiphiles (SSAs) as antimicrobial agents against MRSA and Escherichia coli

Chem Commun (Camb). 2021 Nov 9;57(89):11839-11842. doi: 10.1039/d1cc05455d.

Abstract

Herein, we report a series of di-anionic supramolecular self-associating amphiphiles (SSAs). We elucidate the antimicrobial properties of these SSAs against both methicillin resistant Staphylococcus aureus and Escherichia coli. In addition, we show this class of compound to form both intra- and intermolecular hydrogen bonded macrocyclic structures in the solid state.

MeSH terms

  • Alkanesulfonates / chemistry
  • Alkanesulfonates / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Escherichia coli / drug effects*
  • Hydrogen Bonding
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Phenylurea Compounds / chemistry
  • Phenylurea Compounds / pharmacology*
  • Proton Magnetic Resonance Spectroscopy
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / pharmacology*

Substances

  • Alkanesulfonates
  • Anti-Bacterial Agents
  • Phenylurea Compounds
  • Surface-Active Agents