STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker

Bonan Chen; Wai Nok Chan; Chun Wai Mui; Xiaoli Liu; Jinglin Zhang; Yifei Wang; Alvin H K Cheung; Aden K Y Chan; Ronald C K Chan; Kam Tong Leung; Yujuan Dong; Yi Pan; Huixing Ke; Li Liang; Zhaocai Zhou; Chi Chun Wong; William K K Wu; Alfred S L Cheng; Jun Yu; Kwok Wai Lo; Ka Fai To; Wei Kang

doi:10.1186/s12943-021-01451-2

STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker

Mol Cancer. 2021 Nov 12;20(1):147. doi: 10.1186/s12943-021-01451-2.

Authors

Bonan Chen^#^{1

2

3}, Wai Nok Chan^#^{1

2

3}, Chun Wai Mui^#^{1

2

3}, Xiaoli Liu^{1

2

3}, Jinglin Zhang^{1

2

3}, Yifei Wang^{1

2

3}, Alvin H K Cheung¹, Aden K Y Chan¹, Ronald C K Chan¹, Kam Tong Leung⁴, Yujuan Dong², Yi Pan⁵, Huixing Ke⁶, Li Liang⁷, Zhaocai Zhou⁸, Chi Chun Wong², William K K Wu⁹, Alfred S L Cheng¹⁰, Jun Yu^{2

11}, Kwok Wai Lo^{1

3}, Ka Fai To^{12

13

14}, Wei Kang^{15

16

17}

Affiliations

¹ Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, People's Republic of China.
² Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
³ Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
⁴ Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
⁵ Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
⁶ Department of Respiratory and Critical Care Medicine, China National Center of Gerontology, Bejing Hospital, Beijing, People's Republic of China.
⁷ Department of Pathology, Nanfang Hospital and Basic Medical College, Southern Medical University, Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, People's Republic of China.
⁸ State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
⁹ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
¹⁰ School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
¹¹ Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
¹² Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, People's Republic of China. kfto@cuhk.edu.hk.
¹³ Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China. kfto@cuhk.edu.hk.
¹⁴ Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China. kfto@cuhk.edu.hk.
¹⁵ Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, People's Republic of China. weikang@cuhk.edu.hk.
¹⁶ Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China. weikang@cuhk.edu.hk.
¹⁷ Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China. weikang@cuhk.edu.hk.

^# Contributed equally.

No abstract available

Keywords: Gastric cancer; Oncogene; Ras-MAPK signaling; STK3.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor
Cell Cycle / genetics
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism*
Disease Susceptibility
Gene Expression Regulation, Neoplastic
Humans
Mitogen-Activated Protein Kinases / metabolism*
Oncogenes
Prognosis
Serine-Threonine Kinase 3 / genetics
Serine-Threonine Kinase 3 / metabolism*
Signal Transduction
Stomach Neoplasms / diagnosis
Stomach Neoplasms / etiology*
Stomach Neoplasms / metabolism*
Stomach Neoplasms / mortality
ras Proteins / metabolism*

Substances

Biomarkers, Tumor
STK3 protein, human
Serine-Threonine Kinase 3
Mitogen-Activated Protein Kinases
ras Proteins

Publication types

MeSH terms

Substances

Grants and funding