Impacts of PM2.5 on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment - Two Cities and Two Municipalities, China, 2017-2019

Fangchao Liu; Zhennan Lin; Xinyan Wang; Xueli Yang; Qiong Liu; Xiaolong Xing; Jie Cao; Jianxin Li; Keyong Huang; Weli Yan; Tingting Liu; Wei Li; Shufeng Chen; Xiangfeng Lu; Dongfeng Gu; Jianfeng Huang

doi:10.46234/ccdcw2021.231

Impacts of PM_2.5 on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment - Two Cities and Two Municipalities, China, 2017-2019

China CDC Wkly. 2021 Nov 5;3(45):948-953. doi: 10.46234/ccdcw2021.231.

Authors

Fangchao Liu^{1

2}, Zhennan Lin^{1

2}, Xinyan Wang^{1

2

3}, Xueli Yang⁴, Qiong Liu^{1

2}, Xiaolong Xing^{1

2}, Jie Cao^{1

2}, Jianxin Li^{1

2}, Keyong Huang^{1

2}, Weli Yan⁵, Tingting Liu⁶, Wei Li⁷, Shufeng Chen^{1

2}, Xiangfeng Lu^{1

2}, Dongfeng Gu^{1

2

8}, Jianfeng Huang^{1

2}

Affiliations

¹ Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, China.
³ Center for Reproductive Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China.
⁴ Tianjin Key Laboratory of Environment, Nutrition and Public Health; Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.
⁵ Department of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
⁶ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
⁷ Function Test Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁸ School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Abstract

What is already known about this topic?: Short-term PM_2.5 exposure has been associated with hourly, 24-hour, daytime, and nighttime blood pressure (BP) levels, and further studies focusing whether and how the associations with other ambulatory BP monitoring indicators are warranted.

What is added by this report?: This study observed that short-term PM_2.5 exposure was associated with BP elevations and was the first to report the associations of short-term PM_2.5 exposure with BP variability. Circadian rhythm of BP and BP load among hypertensive patients were found to be modified by controlled BP status or taking angiotensin receptor blockers (ARBs).

What are the implications for public health practice?: This study suggested that antihypertensive therapy, especially with well-controlled BP status may be potential measurements to attenuate adverse impacts of PM_2.5 for hypertensive patients with intermediate-to-high risk of cardiovascular disease (CVD).

Keywords: Ambulatory blood pressure; angiotensin II receptor blocker; blood pressure control; circadian rhythm.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2021.

Grants and funding

The National Key Research and Development Program of China (2016YFC0206503)