RNA processing: Fungal spliceosomes break the mold

Tucker J Carrocci; Aaron A Hoskins

doi:10.1016/j.cub.2021.09.075

RNA processing: Fungal spliceosomes break the mold

Curr Biol. 2021 Nov 22;31(22):R1482-R1484. doi: 10.1016/j.cub.2021.09.075.

Authors

Tucker J Carrocci¹, Aaron A Hoskins²

Affiliations

¹ Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
² Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: ahoskins@wisc.edu.

PMID: 34813754
DOI: 10.1016/j.cub.2021.09.075

Abstract

Dozens of splicing factors work together in human cells to remove introns from nascent RNA transcripts. A new study reveals that spliceosomes from many distantly related fungal species are surprisingly similar to those found in human cells.

Publication types

Comment

MeSH terms

Humans
Introns
RNA Processing, Post-Transcriptional
RNA Splicing*
RNA, Messenger / metabolism
Spliceosomes* / genetics
Spliceosomes* / metabolism

Substances

RNA, Messenger

Grants and funding

R35 GM136261/GM/NIGMS NIH HHS/United States