Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole

J Rheumatol. 1986 Apr;13(2):440-1.

Abstract

A 61-year-old patient with rheumatoid arthritis receiving treatment with methotrexate developed bone marrow hypoplasia after treatment with trimethoprim-sulfamethoxazole. The bone marrow recovered after stopping methotrexate.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy
  • Bone Marrow Diseases / chemically induced*
  • Drug Combinations / adverse effects
  • Drug Combinations / therapeutic use
  • Drug Interactions
  • Female
  • Humans
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Sulfamethoxazole / adverse effects*
  • Sulfamethoxazole / therapeutic use
  • Trimethoprim / adverse effects*
  • Trimethoprim / therapeutic use
  • Trimethoprim, Sulfamethoxazole Drug Combination

Substances

  • Drug Combinations
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole
  • Methotrexate