Sodium Thiosulfate as a Treatment for Calciphylaxis

Natsinee Tangkijngamvong; Paweena Susantitaphong; Numphung Numkarunarunrote; Onanong Jearnsujitwimol; Pravit Asawanonda; Pawinee Rerknimitr

Sodium Thiosulfate as a Treatment for Calciphylaxis

J Clin Aesthet Dermatol. 2021 Oct;14(10):48-51.

Authors

Natsinee Tangkijngamvong^{1

2

3

4}, Paweena Susantitaphong^{1

2

3

4}, Numphung Numkarunarunrote^{1

2

3

4}, Onanong Jearnsujitwimol^{1

2

3

4}, Pravit Asawanonda^{1

2

3

4}, Pawinee Rerknimitr^{1

2

3

4}

Affiliations

¹ Tangkijngamvong, Asawanonda, and Dr. Rerknimitr are with the Division of Dermatology, Department of Medicine, Faculty of Medicine, Skin and Allergy Research Unit, Chulalongkorn University in Bangkok, Thailand.
² Susantitaphong is with the Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand.
³ Numkarunarunrote is with the Department of Radiology, Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand.
⁴ Jearnsujitwimol is with the Division of Nephrology, Department of Medicine, Prapokklao Hospital in Chantaburi, Thailand.

PMID: 34976291
PMCID: PMC8711617

Abstract

The use of sodium thiosulfate has emerged as a promising treatment for calciphylaxis, albeit inconclusively in terms of efficacy and variable outcomes. Research in this field has been limited by a paucity of samples due to the rarity of the disease. We herein discuss eight calciphylaxis patients' responses to STS, the potential predictive factors affecting outcomes and compare our results with previously published literature. We are able to show that lesion severity, concomitant drugs, and dialysis duration may be predictive factors of outcomes. Further, improvement of the wound site may be a clinically relevant prognostic determinant.

Keywords: Calciphylaxis; outcome; sodium thiosulfate.

Publication types

Case Reports