Erector Spina plane (ESP) block; It is a new and simple interfacial area block applied with ultrasonography. ESP is gaining popularity in abdominal and thorax surgery due to its adequate postoperative analgesia, easy administration, and low complication rate. In this case, the postoperative analgesic efficacy of bilateral ESP block performed under the guidance of ultrasonography in a myasthenic patient undergoing thymectomy surgery presented. ESB may be a good option in myasthenic patients in terms of reducing opioid need after thymectomy surgery and preventing possible postoperative complications.