Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma

Olivier Gaide; Fernanda Herrera; Wendy Jeanneret Sozzi; Patrik Gonçalves Jorge; Rémy Kinj; Claude Bailat; Fréderic Duclos; François Bochud; Jean-François Germond; Maud Gondré; Till Boelhen; Luis Schiappacasse; Mahmut Ozsahin; Raphaël Moeckli; Jean Bourhis

doi:10.1016/j.radonc.2021.12.045

Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma

Radiother Oncol. 2022 Sep:174:87-91. doi: 10.1016/j.radonc.2021.12.045. Epub 2022 Jan 5.

Authors

Affiliations

¹ Department of Dermatology, Lausanne University Hospital and University of Lausanne, Switzerland.
² Radiation Oncology Laboratory, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland; Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland.
³ Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland.
⁴ Radiation Oncology Laboratory, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland; Institute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Switzerland.
⁵ Institute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Switzerland.
⁶ Radiation Oncology Laboratory, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland.
⁷ Radiation Oncology Laboratory, Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland; Department of Radiation Oncology, Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address: jean.bourhis@chuv.ch.

PMID: 34998899
DOI: 10.1016/j.radonc.2021.12.045

Abstract

A patient with a cutaneous lymphoma was treated on the same day for 2 distinct tumors using a 15 Gy single electron dose given in a dose rate of 0.08 Gy/second versus 166 Gy/second. Comparing the two treatments, there was no difference for acute reactions, late effects at 2 years and tumor control.

Keywords: Clinical translation; Differential effect; FLASH-RT; Normal skin protection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Neoplasms*
Breast Neoplasms*
Female
Humans
Lymphoma* / radiotherapy
Lymphoma, Non-Hodgkin*
Radiotherapy Dosage
Skin Neoplasms* / radiotherapy