Nanomaterials with changeable physicochemical property for boosting cancer immunotherapy

Qiankun Ni; Fengfei Xu; Yufei Wang; Yujie Li; Guangchao Qing; Yuxuan Zhang; Jie Zhong; Jinghong Li; Xing-Jie Liang

doi:10.1016/j.jconrel.2022.01.003

Nanomaterials with changeable physicochemical property for boosting cancer immunotherapy

J Control Release. 2022 Feb:342:210-227. doi: 10.1016/j.jconrel.2022.01.003. Epub 2022 Jan 6.

Authors

Qiankun Ni¹, Fengfei Xu², Yufei Wang², Yujie Li³, Guangchao Qing², Yuxuan Zhang², Jie Zhong², Jinghong Li⁴, Xing-Jie Liang⁵

Affiliations

¹ Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; Department of Chemistry, Center for BioAnalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
² Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ Department of Chemistry, Center for BioAnalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
⁴ Department of Chemistry, Center for BioAnalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China. Electronic address: jhli@mail.tsinghua.edu.cn.
⁵ Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: liangxj@nanoctr.cn.

PMID: 34998916
DOI: 10.1016/j.jconrel.2022.01.003

Abstract

The past decade has witnessed a great progress in cancer immunotherapy with the sequential approvals of therapeutic cancer vaccine, immune checkpoint inhibitor and chimeric antigen receptor (CAR) T cell therapy. However, some hurdles still remain to the wide implementation of cancer immunotherapy, including low immune response, complex tumor heterogeneity, off-target immunotoxicity, poor solid tumor infiltration, and immune evasion-induced treatment tolerance. Owing to changeable physicochemical properties in response to endogenous or exogenous stimuli, nanomaterials hold the remarkable potential in incorporation of multiple agents, efficient biological barrier penetration, precise immunomodulator delivery, and controllable content release for boosting cancer immunotherapy. Herein, we review the recent advances in nanomaterials with changeable physicochemical property (NCPP) to develop cancer vaccine, remold tumor microenvironment and evoke direct T cell activation. Besides, we provide our outlook on this emerging field at the intersection of NCPP design and cancer immunotherapy.

Keywords: Cancer immunotherapy; Nanomaterial; Nanovaccine; Physicochemical property; T cell therapy; Tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Immunotherapy
Immunotherapy, Adoptive
Nanostructures*
Neoplasms* / pathology
Tumor Microenvironment