A Role of Phosphatidylserine in the Function of Recycling Endosomes

Junya Hasegawa; Yasunori Uchida; Kojiro Mukai; Shoken Lee; Tatsuyuki Matsudaira; Tomohiko Taguchi

doi:10.3389/fcell.2021.783857

A Role of Phosphatidylserine in the Function of Recycling Endosomes

Front Cell Dev Biol. 2021 Dec 24:9:783857. doi: 10.3389/fcell.2021.783857. eCollection 2021.

Authors

Junya Hasegawa¹, Yasunori Uchida¹, Kojiro Mukai¹, Shoken Lee¹, Tatsuyuki Matsudaira¹, Tomohiko Taguchi¹

Affiliation

¹ Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.

Abstract

Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the extracellular space by endocytosis. The removal of PM by endocytosis is constantly balanced by the replenishment of proteins and lipids to PM through recycling pathway. Recycling endosomes (REs) are specific subsets of endosomes. Besides the established role of REs in recycling pathway, recent studies have revealed unanticipated roles of REs in membrane traffic and cell signalling. In this review, we highlight these emerging issues, with a particular focus on phosphatidylserine (PS), a phospholipid that is highly enriched in the cytosolic leaflet of RE membranes. We also discuss the pathogenesis of Hermansky Pudlak syndrome type 2 (HPS2) that arises from mutations in the AP3B1 gene, from the point of view of dysregulated RE functions.

Keywords: bioID proximity labeling; endosomes; flippase; membrane traffic; phosphatidylserine; pleckstrin-homology domain.

Publication types

Review