Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

Blood. 2022 Apr 7;139(14):2252-2256. doi: 10.1182/blood.2021013926.

Noelia Purroy^{1

2

3}, Yuzhou Evelyn Tong^{2

3

4}, Camilla K Lemvigh^{1

5}, Nicoletta Cieri^{1

2

3}, Shuqiang Li^{3

6}, Erin M Parry^{1

2

3}, Wandi Zhang¹, Laura Z Rassenti⁷, Thomas J Kipps⁷, Susan L Slager⁸, Neil E Kay^{8

9}, Connie Lesnick⁹, Tait D Shanafelt¹⁰, Paolo Ghia¹¹, Lydia Scarfò¹¹, Kenneth J Livak^{1

6}, Peter V Kharchenko¹², Donna S Neuberg¹³, Lars Rønn Olsen^{4

5}, Jean Fan¹⁴, Satyen H Gohil^{1

2

3

15}, Catherine J Wu^{1

2

3

16}

¹ Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.
² Harvard Medical School, Boston, MA.
³ Broad Institute, Cambridge, MA.
⁴ Program in Health Sciences and Technology, Harvard Medical School-Massachusetts Institute of Technology, Boston, MA.
⁵ Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.
⁶ Translational Immunogenomics Laboratory, Dana Farber Cancer Institute, Boston, MA.
⁷ Moores Cancer Center, University of California San Diego, La Jolla, CA.
⁸ Department of Health Sciences Research and.
⁹ Department of Medicine, Mayo Clinic, Rochester, MN.
¹⁰ Department of Medicine, Stanford University, Stanford, CA.
¹¹ Division of Experimental Oncology, Department of Onco-Hematology, Università Vita-Salute San Raffaele-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan Italy.
¹² Department of Biomedical Informatics, Harvard Medical School, Boston, MA.
¹³ Department of Data Science, Dana-Farber Cancer Institute, Boston, MA.
¹⁴ Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
¹⁵ Department of Academic Haematology, University College London, United Kingdom; and.
¹⁶ Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

No abstract available

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