Recent research progress of biologically active peptides

Biofactors. 2022 May;48(3):575-596. doi: 10.1002/biof.1822. Epub 2022 Jan 25.

Abstract

With the rapid development of molecular biology and biochemical technology, great progress has been made in the study of peptides. Peptides are easy to digest and absorb, with lowering of blood pressure and cholesterol, improving immunity, regulating hormones, antibacterial, and antiviral effects. Peptides also have physiological regulation and biological metabolism functions with applications in the fields of feed production and biomedical research. In the future, the research focus of bioactive peptides will focus on their efficient preparation and application. This article introduces a comprehensive review of the types, synthesis, functionalization, and bio-related applications of bioactive peptides. For this aim, we introduced in detail various biopeptides and then presented the production methods of bioactive peptides, such as enzymatic synthesis, microbial fermentation, chemical synthesis, and others. The applications of bioactive peptides for anticancers, immune therapy, antibacterial, and other applications have been introduced and discussed. And discussed the development prospects of biologically active peptides.

Keywords: antibacterial and antiviral peptides; anticancer peptides; bioactive peptides; cosmetic peptide; drug carrier peptide; immune peptide.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents*
  • Peptides* / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Peptides