Graft dysfunction and rejection of lung transplant, a review on diagnosis and management

Abstract

Introduction: Lung transplantation has proven to be an effective treatment option for end-stage lung disease. However, early and late complications following transplantation remain significant causes of high mortality.

Objectives: In this review, we focus on the time of onset in primary graft dysfunction and rejection complications, as well as emphasize the role of imaging manifestations and pathological features in early diagnosis, thus assisting clinicians in the early detection and treatment of posttransplant complications and improving patient quality of life and survival.

Data source: We searched electronic databases such as PubMed, Web of Science, and EMBASE. We used the following search terms: lung transplantation complications, primary graft dysfunction, acute rejection, chronic lung allograft dysfunction, radiological findings, and diagnosis and treatment.

Conclusion: Primary graft dysfunction, surgical complications, immune rejection, infections, and neoplasms represent major posttransplant complications. As the main posttransplant survival limitation, chronic lung allograft dysfunction has a characteristic imaging presentation; nevertheless, the clinical and imaging manifestations are often complex and overlap, so it is essential to understand the temporal evolution of these complications to narrow the differential diagnosis for early treatment to improve prognosis.

Keywords: chronic lung allograft dysfunction; lung transplantation complications; primary graft dysfunction; radiological findings; treatment.