Metabolic indexes of obesity in patients with common mental disorders in stable stage

Abstract

Background: Obesity is a serious worldwide public health problem, especially for people with mental disorders.

Aim: To explore the related factors of obesity by analyzing the metabolic indexes of patients with common mental disorders in stable stage.

Methods: Five hundred seventy-six subjects with major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ) were included, who received fixed drug dose and routine drug treatment for 2 years or more. Their venous blood was collected, and the blood metabolic indexes were analyzed.

Results: BD and SCZ are more prone to obesity than MDD. Multiple linear regression analysis showed that the value of BMI increased with the increase of age(B = 0.084, p < 0.001), TG(B = 0.355, p = 0.024), LDL(B = 0.697, p < 0.001), LDH(B = 0.011, p = 0.002), SCr(B = 0.051, p < 0.001), UA(B = 0.014, p < 0.001), HbA1c(B = 0.702, p = 0.004) and hsCRP(B = 0.101, p < 0.001). And It decreased with the increase of HDL(B = -1.493, p < 0.001).

Discussion: People with mental disorders should regularly check blood indicators and strengthen weight management to reduce the risk of obesity and promote their health.

Keywords: Bipolar disorder; Body mass index; Major depressive disorder; Obesity; Schizophrenia.