Methotrexate resistance and gene amplification. Mechanisms and implications

Cancer. 1986 May 15;57(10):1912-7. doi: 10.1002/1097-0142(19860515)57:10<1912::aid-cncr2820571004>3.0.co;2-o.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cells, Cultured
  • Chromosome Aberrations
  • Chromosome Fragility
  • DNA Replication
  • Drug Resistance*
  • Gene Amplification*
  • Humans
  • Methotrexate / pharmacology*
  • Neoplasms / drug therapy
  • Tetrahydrofolate Dehydrogenase / genetics*

Substances

  • Tetrahydrofolate Dehydrogenase
  • Methotrexate