Platelet phagocytosis by leukocytes in a patient with cerebral hemorrhage and thrombocytopenia caused by gram-negative bacterial infection

J Int Med Res. 2022 Feb;50(2):3000605221079102. doi: 10.1177/03000605221079102.

Abstract

Bacteria-induced thrombocytopenia is a common clinical disease that is often ignored by clinical and scientific research. Thus, exploring the mechanism and principle of bacteria-induced thrombocytopenia could facilitate the development of new diagnostic, preventative, and treatment modalities for thrombocytopenia. This case report describes a case of platelet phagocytosis by neutrophils and monocytes in a patient with cerebral hemorrhage and thrombocytopenia caused by gram-negative bacterial infection. After the infection was eradicated, platelet phagocytosis was alleviated, and his platelet count normalized. Cellular immunity may be an important cause of bacteria-induced thrombocytopenia in patients with cerebral hemorrhage.

Keywords: Cerebral haemorrhage; bacterial infection; case report; leukocyte; neutrophil; phagocytosis; thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Blood Platelets
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / diagnostic imaging
  • Gram-Negative Bacterial Infections* / complications
  • Humans
  • Leukocytes
  • Phagocytosis
  • Thrombocytopenia* / etiology