Non-Apoptotic Role of Apoptotic Caspases in the Drosophila Nervous System

Abstract

An increasing number of studies demonstrate that cells can activate apoptotic caspases but not die and, instead, display profound changes in cellular structure and function. In this minireview, we will discuss observations in the nervous system of Drosophila melanogaster that illustrate non-apoptotic roles of apoptotic caspases. We will preface these examples with similar observations in other experimental systems and end with a discussion of how apoptotic caspase activity might be constrained to provide non-lethal functions without killing the cell.

Keywords: Drosophila; apoptosis; caspase; central nervous system; peripheral nervous system.