Preparation of the Biodegradable Lymphatic Targeting Imaging Agent Based on the Indocyanine Green Mesoporous Silicon System

Man Duan; Dongmei Han; Wenbin Shen; Kun Chang; Xinyu Wang; Nan Gao; Jianshi Du

doi:10.3389/fchem.2022.847929

Preparation of the Biodegradable Lymphatic Targeting Imaging Agent Based on the Indocyanine Green Mesoporous Silicon System

Front Chem. 2022 Feb 22:10:847929. doi: 10.3389/fchem.2022.847929. eCollection 2022.

Authors

Man Duan¹, Dongmei Han¹, Wenbin Shen², Kun Chang², Xinyu Wang¹, Nan Gao³, Jianshi Du¹

Affiliations

¹ Key Laboratory of Lymphatic Surgery Jilin Province, Jilin Engineering Laboratory for Lymphatic Surgery Jilin Province, China-Japan Union Hospital of Jilin University, Changchun, China.
² Department of Lymphology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
³ Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun, China.

Abstract

The lymphatic system plays a crucial role in the immune system's recognition and response to disease. Therefore, the imaging of the lymphatic system, especially lymphatic vessels, has emerged as a valuable tool for the diagnosis of metastasis. FDA-approved small-molecule dyes, namely, indocyanine green (ICG), have been widely applied to lymphatic vessels imaging. However, due to the small physical size, such molecule-based agents show no selectivity, and rapid clearance from lymph nodes. Herein, a biodegradable lymphatic targeting imaging agent based on the ICG-mesoporous silicon system (ICG@HMONs-HA) was obtained, which not only could target lymph vessels but also had a long residence time. The reported work provides a practical way for lymph vessel fluorescence imaging and paves the way for clinical translation of nanomaterial-based tracers.

Keywords: LYVE-1; hyaluronic acid; indocyanine green; lymph vessel; mesoporous silicon.