Platelets and mast cells say "HIAA" to welcome in neutrophils

Sci Immunol. 2022 Apr;7(70):eabq1730. doi: 10.1126/sciimmunol.abq1730. Epub 2022 Apr 1.

Author

Andrew Lichtman¹

Affiliation

¹ Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Email: alichtman@bwh.harvard.edu.

PMID: 35363542
DOI: 10.1126/sciimmunol.abq1730

Abstract

Platelet- and mast cell-derived serotonin metabolite 5-HIAA binding to GPR35 mediates neutrophil recruitment to acute inflammatory sites.

Publication types

Comment

MeSH terms

Blood Platelets* / metabolism
Mast Cells
Neutrophil Infiltration
Neutrophils*