Atherosclerosis: From Molecular Biology to Therapeutic Perspective

Int J Mol Sci. 2022 Mar 22;23(7):3444. doi: 10.3390/ijms23073444.

Abstract

Atherosclerosis is a chronic and progressive inflammatory disease of the arteries initiated by the functional and structural alteration of the endothelial layer responsible for promoting the subendothelial retention of modified low-density lipoproteins (LDL), which in turn generate an active proinflammatory state in which environmental factors, such as oxidizing agents, growth factors, cytokines, monocyte-macrophages and smooth muscle cells (SMCs), work in cooperation to promote the formation of plaque [...].

Publication types

  • Editorial

MeSH terms

  • Atherosclerosis* / genetics
  • Atherosclerosis* / metabolism
  • Atherosclerosis* / therapy
  • Humans
  • Lipoproteins, LDL / metabolism
  • Molecular Biology
  • Muscle, Smooth, Vascular / metabolism
  • Myocytes, Smooth Muscle / metabolism
  • Plaque, Atherosclerotic* / metabolism
  • Plaque, Atherosclerotic* / therapy

Substances

  • Lipoproteins, LDL