Superior cervical ganglionectomy alters gut microbiota in rats

Wencui Zhang; Yujuan Li; Tianning Sun; Zhixiao Li; Anne Manyande; Weiguo Xu; Maohui Feng; Hongbing Xiang

Superior cervical ganglionectomy alters gut microbiota in rats

Am J Transl Res. 2022 Mar 15;14(3):2037-2050. eCollection 2022.

Authors

Wencui Zhang¹, Yujuan Li¹, Tianning Sun¹, Zhixiao Li¹, Anne Manyande², Weiguo Xu³, Maohui Feng⁴, Hongbing Xiang¹

Affiliations

¹ Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, China.
² School of Human and Social Sciences, University of West London London, UK.
³ Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, China.
⁴ Department of Gastrointestinal Surgery, Wuhan Peritoneal Cancer Clinical Medical Research Center, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center Wuhan 430071, Hubei, China.

PMID: 35422915
PMCID: PMC8991167

Abstract

The diversity and complexity of sympathetic function highlight the importance of fundamental research. Little is known about the interaction of superior cervical sympathetic ganglion (SCG) and gut microbiota. In this study, the engagement of the sympathetic ganglia with gut microbiota was investigated. Bilateral superior cervical ganglionectomy (SCGx) significantly altered the microbiota composition in rats 14 days post-surgery, and these microbiotas may participate in several biological pathways in the host, suggesting the vital role of the cervical sympathetic ganglion in regulating the microbiome-brain axis, and further confirming that the sympathetic nervous system (SNS) regulates the microbiome-brain axis.

Keywords: Superior cervical sympathetic ganglion; gut microbiota; superior cervical ganglionectomy; sympathetic nervous system.