How to choose a high-efficiency, green and inherent safety synthetic route is an important issue for the development of the chemical industry. "Three-parameter difference" is a complex parameter with the calculation of Gibbs free energy, atom utilization and inherent safety index, and can be used to comprehensively evaluate the thermodynamic feasibility, greenness and safety of chemical reactions. This parameter has been proposed and established, but the reliability has not been determined. In this study, the parameter has been corrected to make it more universal. It was calculated and studied in the synthesis of dimethyl carbonate and toluene diisocyanate, separately. The results showed that the reaction pathways for synthesizing dimethyl carbonate from the gas-phase oxidative carbonylation of methanol by a one-step process, and toluene diisocyanate from dimethyl carbonate-ionic liquid hydroxylamine have obvious advantages and future research prospects. They are consistent with the existing actual research, which can prove the reliability of the "three-parameter difference". More importantly, the parameter provides a theoretical basis and has an adequate practical guidance significance to design and evaluate a new synthesis route.
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