Missed abortion with negative biomarkers

Am J Emerg Med. 2022 Jul:57:236.e5-236.e6. doi: 10.1016/j.ajem.2022.04.028. Epub 2022 Apr 25.

Abstract

Background: First-trimester bleeding and pregnancy loss are common reasons for presentation to emergency departments. Women of childbearing age frequently receive urine and serum pregnancy tests, which are thought to be reliable markers of pregnancy.

Case presentation: We report a case of a 34-year-old woman who presented to an emergency department with vaginal bleeding and abdominal pain and was found to have negative urine and serum markers of pregnancy. A transvaginal ultrasound detected non-viable fetal tissue and the patient underwent an uncomplicated spontaneous abortion.

Conclusions: Physicians should consider the use of ultrasonography to assess for pregnancy or retained fetal products in the appropriate patient, even with negative serum or urine markers of pregnancy.

Keywords: Gynecology; Ultrasonography.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Missed* / diagnostic imaging
  • Abortion, Spontaneous*
  • Adult
  • Biomarkers
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Trimester, First
  • Ultrasonography
  • Uterine Hemorrhage / etiology

Substances

  • Biomarkers