Electron Transfer Strategies to Regulate Carriers' Separation for Intensive Pyroelectric Dynamic Therapy With Simultaneous Photothermal Therapy

Bingxia Sun; Yun Meng; Tianlin Song; Jieyun Shi; Xinhong He; Peiran Zhao

doi:10.3389/fchem.2022.874641

Electron Transfer Strategies to Regulate Carriers' Separation for Intensive Pyroelectric Dynamic Therapy With Simultaneous Photothermal Therapy

Front Chem. 2022 Apr 12:10:874641. doi: 10.3389/fchem.2022.874641. eCollection 2022.

Authors

Bingxia Sun¹, Yun Meng², Tianlin Song², Jieyun Shi², Xinhong He³, Peiran Zhao^{1

4}

Affiliations

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
² Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
³ Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴ Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China.

Abstract

Endogenic heat shock proteins and uneven local heat distribution are two main problems in traditional tumor hyperthermia therapy strategies. Aiming at solving these problems, we designed Au-SnSe-PVP nanomaterials (ASNPs) by modifying Au nanoparticles (Au-NPs) and biocompatible PVP on SnSe nanorods via a new reactive oxygen species production strategy. The ASNPs with excellent photothermal conversion performance can produce thermoelectric effects in response to temperature differences during photothermal conversion. The modification of Au-NPs can attract free electron (e^-) to accumulate and promote the separation of e^- and holes (h⁺) in the thermoelectric process, thereby further promoting e^--rich Au-NPs-induced H₂O₂ homolysis and h⁺-H₂O half-reaction to generate hydroxyl radicals, realizing the synergistic application of photothermal therapy and pyroelectric dynamic therapy in tumor treatment.

Keywords: Au–SnSe–PVP nanomaterials; hydroxyl radical; photothermal therapy; pyroelectric dynamic therapy; separation of electrons and holes.