TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease

Rika Yamashita; Goichi Beck; Yuki Yonenobu; Kimiko Inoue; Akihiko Mitsutake; Hiroyuki Ishiura; Masato Hasegawa; Shigeo Murayama; Hideki Mochizuki

doi:10.1002/mds.29048

TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease

Mov Disord. 2022 Jul;37(7):1561-1563. doi: 10.1002/mds.29048. Epub 2022 May 9.

Authors

Affiliations

¹ Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
² Department of Neurology, NHO Osaka Toneyama Medical Center, Toyonaka, Japan.
³ Department of Neurology, The University of Tokyo, Tokyo, Japan.
⁴ Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
⁵ Department of Neurology and Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
⁶ Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan.

PMID: 35531755
DOI: 10.1002/mds.29048

Abstract

Accumulation of abnormal transactivation response DNA-binding protein of 43 kDa (TDP-43) independently induces dopaminergic neuronal loss in the substantia nigra without Lewy pathology, and results in typical Parkinson's disease-like motor symptoms.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Dopamine / metabolism
Humans
Parkinson Disease* / metabolism
Substantia Nigra / metabolism
TDP-43 Proteinopathies* / metabolism

Substances

Dopamine