Developing techniques for the highly sensitive assay of neurotransmitters is essential for understanding physiological and pathological processes. Here, we demonstrate a fast-scanning potential (FSP)-gated organic electrochemical transistor (OECT): for the highly sensitive sensing of dopamine (DA) in a living rat brain. The configuration combines the selectivity of fast-scan cyclic voltammetry (FSCV) with the high sensitivity of an OECT. The combined use of FSP as a gating mode and transconductance (gm ) as a sensing parameter further improve the sensing performance in terms of sensitivity, limit of detection, reproducibility, and stability. The FSP-OECT exhibits a sensitivity of 0.899 S M-1 and a low limit of detection down to 5 nM and was validated for in vivo monitoring of the basal level and electrically stimulated release of DA.
Keywords: Dopamine; Fast-Scanning Potential Gating; In Vivo Analysis; Organic Electrochemical Transistors.
© 2022 Wiley-VCH GmbH.