Redoxing PTPN22 activity

Elife. 2022 May 19:11:e79125. doi: 10.7554/eLife.79125.

Abstract

The oxidative state of a critical cysteine residue determines the enzymatic activity of a phosphatase involved in T-cell immune responses.

Keywords: PTPN22; Redox; T cells; immunology; inflammation; mouse.

Publication types

  • Editorial

MeSH terms

  • Immunity
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22* / genetics
  • T-Lymphocytes*

Substances

  • Protein Tyrosine Phosphatase, Non-Receptor Type 22