Superchaotropic Boron Clusters as Membrane Carriers for the Transport of Hydrophilic Cargos

Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202204979. doi: 10.1002/anie.202204979. Epub 2022 May 19.

Abstract

Design of membrane transporters is important in pharmaceutical drug delivery and bioimaging. Traditionally, the amphiphilic transport mechanism has governed the design of membrane carriers over the last 50 years. Recently, Montenegro, Nau and co-workers discarded classical amphiphilic models and proposed a new transport principle based on the chaotropic effect. They utilized globular boron clusters as membrane carriers to transport a broad range of hydrophilic cargo. Herein, we highlight this recent pioneering work, which is a landmark for membrane transport.

Keywords: Boron Clusters; Carriers; Drug Delivery; Membrane Transport; Superchaotropic.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Boron*
  • Drug Carriers
  • Drug Delivery Systems*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Pharmaceutical Preparations

Substances

  • Drug Carriers
  • Pharmaceutical Preparations
  • Boron