Heart failure affects ∼64 million people worldwide, resulting in high morbidity, mortality and societal cost. Current treatment strategies are primarily geared at slowing the progression to an advanced disease state, but do not reverse or cure heart failure. A more comprehensive understanding of the underlying biology and development of preclinical models of this heterogeneous group of disorders will improve diagnosis and treatment. Here, we summarise recent preclinical and translational research in this area published in Disease Models & Mechanisms. We also discuss how our Journal is propelling this field forward by launching a Special Issue and ongoing subject collection, 'Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy'.
Keywords: Cardiac regeneration; Heart disease; Heart failure.
© 2022. Published by The Company of Biologists Ltd.