Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure

Circulation. 2022 May 24;145(21):1625-1628. doi: 10.1161/CIRCULATIONAHA.121.057879. Epub 2022 May 23.

¹ Center for Translational Medicine, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (A.A.G., E.K.M., A.T.H., R.B.G., T.L.P., A.A.L., R.R., J.W.E.).
² Cardiovascular Institute and Cardiovascular Medicine Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (K.B., Z.A., D.P.K., K.B.M.).
³ Department of Chemistry (P.K.L.), University of Louisville, KY.
⁴ Division of Environmental Medicine (B.G.H.), University of Louisville, KY.

No abstract available

Keywords: fibrosis; glutamine; heart failure; metabolism; myofibroblasts.

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