m1A RNA Modification in Gene Expression Regulation

Hao Jin; Chunxiao Huo; Tianhua Zhou; Shanshan Xie

doi:10.3390/genes13050910

m¹A RNA Modification in Gene Expression Regulation

Genes (Basel). 2022 May 19;13(5):910. doi: 10.3390/genes13050910.

Authors

Hao Jin^{1

2}, Chunxiao Huo², Tianhua Zhou^{2

3}, Shanshan Xie^{1

2}

Affiliations

¹ The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
² Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
³ Cancer Center, Zhejiang University, Hangzhou 310058, China.

Abstract

N¹-methyladenosine (m¹A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m¹A RNA modification in gene regulation and biological processes. In this review, we focus on progress in the study of m¹A methyltransferases, m¹A demethylases and m¹A-dependent RNA-binding proteins and highlight the biological mechanisms and functions of m¹A RNA modification, as well as its association with human disease. We also summarize the current understanding of detection approaches for m¹A RNA modification.

Keywords: N1-methyladenosine(m1A); RNA modification; gene expression.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adenosine* / genetics
Adenosine* / metabolism
Gene Expression Regulation* / genetics
Humans
Methylation
RNA Processing, Post-Transcriptional
RNA, Messenger / genetics
RNA, Messenger / metabolism

Substances

RNA, Messenger
Adenosine

Grants and funding

This research was funded by the Chinese National Natural Scientific Foundation Grants, grant number U21A20197.