Sleep Deprivation and Circadian Disruption Stress, Allostasis, and Allostatic Load

Bruce S McEwen; Ilia N Karatsoreos

doi:10.1016/j.jsmc.2022.03.005

Sleep Deprivation and Circadian Disruption Stress, Allostasis, and Allostatic Load

Sleep Med Clin. 2022 Jun;17(2):253-262. doi: 10.1016/j.jsmc.2022.03.005. Epub 2022 Apr 23.

Authors

Bruce S McEwen¹, Ilia N Karatsoreos²

Affiliations

¹ Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
² Department of Psychological and Brain Sciences, Neuroscience and Behavior Program, University of Massachusetts Amherst, Tobin Hall, 135 Hicks Way, Amherst, MA 01003, USA. Electronic address: ikaratsoreos@umass.edu.

PMID: 35659078
DOI: 10.1016/j.jsmc.2022.03.005

Abstract

Getting a good night's sleep seems a panacea for improving mood and cognition. These subjective impressions are supported by countless studies exploring the impacts of sleep (and sleep loss) on mental health, metabolism, and immune function. Similarly, being "out of phase" with local time, commonly experienced by shift workers of jet-lagged air travelers, demonstrates that there are both neural and physiologic effects of internal circadian (daily) time being misaligned with external environmental time. This article reviews these areas contextualized using the model of allostasis and allostatic load emphasizing the impact of this "wear and tear" on the brain and body.

Keywords: Allostasis; Allostatic load; Circadian disruption; Glycogen; Hippocampus; Oxidative stress; Proinflammatory cytokines; Sleep deprivation.

Publication types

Review

MeSH terms

Allostasis* / physiology
Brain / physiology
Humans
Sleep
Sleep Deprivation
Stress, Psychological / psychology