Biting into a union of oncology and metabolism through leukemic stem cells

Mickie Bhatia; Amro Elrafie

doi:10.1016/j.cmet.2022.05.006

Biting into a union of oncology and metabolism through leukemic stem cells

Cell Metab. 2022 Jun 7;34(6):801-802. doi: 10.1016/j.cmet.2022.05.006.

Authors

Mickie Bhatia¹, Amro Elrafie²

Affiliations

¹ Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. Electronic address: mbhatia@mcmaster.ca.
² Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

PMID: 35675797
DOI: 10.1016/j.cmet.2022.05.006

Abstract

In this issue of Cell Metabolism, Liu et al. demonstrate that Prmt7 can regulate the onset and progression of leukemogenesis by inhibiting self-renewal capacity of leukemic stem cells (LSCs) as modeled in a murine version of chronic myeloid leukemia (CML).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / metabolism
Mice
Neoplastic Stem Cells* / metabolism
Protein-Arginine N-Methyltransferases / metabolism

Substances

PRMT7 protein, mouse
Protein-Arginine N-Methyltransferases

Grants and funding

159925 /CIHR/Canada