Primary Clonal Loss of Mismatch Repair Protein on Immunohistochemistry: A Pattern of Abnormality That Warrants Genetic Workup

JCO Precis Oncol. 2022 Jun:6:e2200111. doi: 10.1200/PO.22.00111.

Authors

Christine Orr^{1

2}, Chiyun Wang¹, Canan Firat¹, Louise C Connell³, Margaret R Sheehan³, Efsevia Vakiani¹, Zsofia K Stadler³, Jinru Shia¹

Affiliations

¹ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
² Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
³ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

DNA Mismatch Repair* / genetics
Immunohistochemistry
Mismatch Repair Endonuclease PMS2 / genetics
MutS Homolog 2 Protein / genetics

Substances

Mismatch Repair Endonuclease PMS2
MutS Homolog 2 Protein

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States