LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling

Jiecheng Yang; Fangzhou Liu; Ying Wang; Lei Qu; Aifu Lin

doi:10.1016/j.canlet.2022.215798

LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling

Cancer Lett. 2022 Sep 1:543:215798. doi: 10.1016/j.canlet.2022.215798. Epub 2022 Jun 20.

Authors

Jiecheng Yang¹, Fangzhou Liu¹, Ying Wang¹, Lei Qu¹, Aifu Lin²

Affiliations

¹ MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang, 310058, China.
² MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang, 310058, China; Breast Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China; International School of Medicine, International Institutes of Medicine, The 4th Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, China; ZJU-QILU Joint Research Institute, Hangzhou, Zhejiang, 310058, China. Electronic address: linaifu@zju.edu.cn.

PMID: 35738332
DOI: 10.1016/j.canlet.2022.215798

Abstract

Evidence accumulated over the past decade has verified that long non-coding RNAs (lncRNAs) exert important functions in multiple cell programs. As a novel class of cellular regulatory molecules, lncRNAs interact with different molecules, such as DNA, RNA or proteins, depending on their subcellular distribution, to modulate gene transcription and kinase cascades. It has been widely clarified that lncRNAs play important roles in modulating metabolic reprogramming and reshaping the immune landscape and serve as hinges bridging tumor metabolism and anti-tumor immunity. Given these facts, lncRNAs, as putative regulators of tumor initiation and progression, have attracted extensive attention in recent years. In this review, we summarized the current research progress on the role of lncRNAs in tumor metabolic reprogramming and tumor-immune microenvironment remodeling, and conclude with our laboratory's contributions in advancing the clinical applications of lncRNAs.

Keywords: Amino acid metabolism; Glycolysis; Lipid metabolism; LncRNA; Tumor immunity; Tumor immunotherapy; Tumor microenvironment.

Publication types

Review

MeSH terms

Humans
Neoplasms* / pathology
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Tumor Microenvironment / genetics

Substances

RNA, Long Noncoding