Effect of echinomycin on DNA methylation

FEBS Lett. 1987 May 11;215(2):266-8. doi: 10.1016/0014-5793(87)80159-x.

Abstract

Although echinomycin is reported to intercalate and to bind to DNA at CG dinucleotides, the effects of the drug on DNA methylation in vitro and in vivo are much less apparent than are the effects on DNA synthesis and cell growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division / drug effects
  • DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors
  • DNA / biosynthesis
  • DNA / metabolism*
  • Echinomycin / pharmacology*
  • L Cells / drug effects
  • Methylation
  • Mice
  • Quinoxalines / pharmacology*

Substances

  • Quinoxalines
  • Echinomycin
  • DNA
  • DNA (Cytosine-5-)-Methyltransferases