Short-Term Prognostic Efficacy of mGPS and LCS in Patients With Acute Heart Failure

Jing Wang; Ling Xie; Ping Lyu; Feng Zhou; Hong-Li Cai; Rong-Xing Qi; Qing Zhang

doi:10.3389/fcvm.2022.944424

Short-Term Prognostic Efficacy of mGPS and LCS in Patients With Acute Heart Failure

Front Cardiovasc Med. 2022 Jul 5:9:944424. doi: 10.3389/fcvm.2022.944424. eCollection 2022.

Authors

Jing Wang¹, Ling Xie¹, Ping Lyu¹, Feng Zhou², Hong-Li Cai³, Rong-Xing Qi⁴, Qing Zhang³

Affiliations

¹ Department of Cardiology, Affiliated Hospital 2 of Nantong University, Nantong, China.
² Department of Clinical Laboratory, Affiliated Hospital 2 of Nantong University, Nantong, China.
³ Department of General Practice, Affiliated Hospital 2 of Nantong University, Nantong, China.
⁴ Department of Image, Affiliated Hospital 2 of Nantong University, Nantong, China.

Abstract

Aim: Systemic inflammation plays an important role in the occurrence and development of acute heart failure. The modified Glasgow Prognostic Score (mGPS) and "lymphocyte C-reactive protein score" (LCS) are used to assess the inflammation levels in cancer patients. The purpose of this study was to assess the prognostic value of these two inflammation-related scoring systems in patients with acute heart failure.

Methods: Two hundred and fifty patients with acute heart failure were enrolled in this study. The mGPS and LCS scores were recorded after admission. All patients were divided into 2 groups: the death group and the survival group according to the 3-month follow-up results. The predictive values of mGPS and LCS were assessed using receiver-operating characteristic (ROC) analyses. Univariate and multivariate logistic analyses were used to evaluate the relationships between variables and endpoint.

Results: The levels of mGPS and LCS in the death group were significantly higher than those in the survival group (P < 0.05). The areas under the ROC curve of the mGPS and LCS for predicting death were 0.695 (95%CI: 0.567~0.823) and 0.736 (95%CI: 0.616~0.856), respectively. Multivariate analysis demonstrated that both LCS, LVEF and serum direct bilirubin were independent predictors of all-cause death, excluding mGPS.

Conclusions: Compared with mGPS, LCS is independently associated with short-term outcomes in patients with acute heart failure. LCS was a clinically promising and feasible prognostic scoring system for patients with acute heart failure.

Keywords: LCS; acute heart failure; inflammation; mGPS; prognosis.