Junctional Adhesion Molecules: Potential Proteins in Atherosclerosis

Junqi Wang; Xiaoping Chen

doi:10.3389/fcvm.2022.888818

Junctional Adhesion Molecules: Potential Proteins in Atherosclerosis

Front Cardiovasc Med. 2022 Jul 7:9:888818. doi: 10.3389/fcvm.2022.888818. eCollection 2022.

Authors

Junqi Wang^{1

2

3}, Xiaoping Chen^{1

2

3}

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
² Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Junctional adhesion molecules (JAMs) are cell-cell adhesion molecules of the immunoglobulin superfamily and are involved in the regulation of diverse atherosclerosis-related processes such as endothelial barrier maintenance, leucocytes transendothelial migration, and angiogenesis. To combine and further broaden related results, this review concluded the recent progress in the roles of JAMs and predicted future studies of JAMs in the development of atherosclerosis.

Keywords: atherosclerosis; inflammation; junctional adhesion molecules; thrombosis; transendothelial migration.

Publication types

Review