Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature

Jessica El Halabi; Lisa LaGuardia; R Matthew Walsh; Choon Hyuck David Kwon; K V Narayanan Menon; David Liska; Carol A Burke

doi:10.1007/s10689-022-00305-0

Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature

Fam Cancer. 2023 Jan;22(1):77-82. doi: 10.1007/s10689-022-00305-0. Epub 2022 Jul 28.

Authors

Jessica El Halabi¹, Lisa LaGuardia^{2

3}, R Matthew Walsh^{4

3}, Choon Hyuck David Kwon⁴, K V Narayanan Menon⁵, David Liska^{2

3}, Carol A Burke^{6

7}

Affiliations

¹ Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
² Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA.
³ Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA.
⁴ Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
⁵ Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Mail Code A30, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
⁶ Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Mail Code A30, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. burkec1@ccf.org.
⁷ Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. burkec1@ccf.org.

PMID: 35896845
DOI: 10.1007/s10689-022-00305-0

Abstract

Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and hepatocellular carcinoma are rare in FAP. In this case series, we describe a mother and daughter with FAP who developed a hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas, respectively.

Keywords: Familial adenomatosous polyposis; Hepatocellular carcinoma; Solid pseudopapillary neoplasm of the pancreas.

Publication types

Review
Case Reports

MeSH terms

Adenocarcinoma* / pathology
Adenomatous Polyposis Coli* / complications
Adenomatous Polyposis Coli* / pathology
Carcinoma, Hepatocellular* / etiology
Carcinoma, Hepatocellular* / pathology
Humans
Liver Neoplasms* / etiology
Liver Neoplasms* / pathology
Pancreas / pathology