Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

Philip Mzyk; Humberto Hernandez; Thanh Le; Jose Ricardo Ramirez; Colleen M McDowell

doi:10.3389/fcell.2022.936115

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

Front Cell Dev Biol. 2022 Jul 15:10:936115. doi: 10.3389/fcell.2022.936115. eCollection 2022.

Authors

Philip Mzyk¹, Humberto Hernandez², Thanh Le², Jose Ricardo Ramirez², Colleen M McDowell¹

Affiliations

¹ University of Wisconsin-Madison, Madison, WI, United States.
² University of Houston-Victoria, Victoria, TX, United States.

Abstract

Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure.

Keywords: ECM; TLR4; glaucoma; intraocular pressure; trabecular meshwork.

Publication types

Review

Abstract

Publication types

Grants and funding