A dual-responsive "Yin-Yang" photothermal delivery system to accelerate Parthenolide anti-tumor efficacy

Anshuo Li; Wenbin Gao; Xuwu Zhang; Yuwei Deng; Yuhui Zhu; Hao Gu; Jin Wen; Xinquan Jiang

doi:10.1016/j.bioadv.2022.212935

A dual-responsive "Yin-Yang" photothermal delivery system to accelerate Parthenolide anti-tumor efficacy

Biomater Adv. 2022 Jul:138:212935. doi: 10.1016/j.bioadv.2022.212935. Epub 2022 May 25.

Authors

Anshuo Li¹, Wenbin Gao², Xuwu Zhang², Yuwei Deng¹, Yuhui Zhu¹, Hao Gu¹, Jin Wen³, Xinquan Jiang⁴

Affiliations

¹ Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.
² Nano-biotechnology Key Lab of Hebei Province, Chemical Key Lab of Hebei Province Department of Biological Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
³ Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China. Electronic address: echomet@126.com.
⁴ Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China. Electronic address: xinquanjiang@aliyun.com.

PMID: 35913256
DOI: 10.1016/j.bioadv.2022.212935

Abstract

Parthenolide (PTL), a germacrane sesquiterpene lactone extracted from the "Yin" Chinese traditional herb feverfew, has gained interest due to its lethal effects on tumor cells and its pharmacological effects within traditional Chinese medicine theory. To overcome low, non-targeted accumulation and uncontrolled release of PTL administration, a dual-responsive PTL-liposomes@chitosan@gold nanoshells (PTL-Lips@CS@GNS) system was fabricated. Hyperthermia generated under light irradiation in the near-infrared region via local surface plasmon resonance of gold nanoshells induced photothermal therapy, which also stimulated PTL release due to the liposomes gel-to-liquid crystalline phase transition. Additionally, PTL-Lips@CS@GNS exhibited a pH-responsive release in the acidic tumor microenvironment. Collectively, this study provides a realistic strategy for an effective combination of traditional Chinese medicine and current nanotechnology for tumor therapy.

Keywords: Dual-responsive release; Nano-drug delivery system; Parthenolide; Photothermal therapy; Traditional Chinese medicine.

MeSH terms

Antineoplastic Agents* / pharmacology
Gold / chemistry
Humans
Hyperthermia, Induced*
Liposomes / chemistry
Neoplasms*
Phototherapy
Sesquiterpenes
Tumor Microenvironment

Substances

Antineoplastic Agents
Liposomes
Sesquiterpenes
parthenolide
Gold