Successful transcatheter mitral valve repair with the MitraClip system in a patient with Duchenne muscular dystrophy

Mike Saji; Kojiro Sakurai; Yuki Izumi; Satoshi Yazaki; Ryosuke Higuchi; Kazuhiko Segawa; Itaru Takamisawa

doi:10.1016/j.jccase.2022.02.007

Successful transcatheter mitral valve repair with the MitraClip system in a patient with Duchenne muscular dystrophy

J Cardiol Cases. 2022 Mar 23;26(1):59-61. doi: 10.1016/j.jccase.2022.02.007. eCollection 2022 Jul.

Authors

Mike Saji¹, Kojiro Sakurai¹, Yuki Izumi¹, Satoshi Yazaki², Ryosuke Higuchi¹, Kazuhiko Segawa³, Itaru Takamisawa¹

Affiliations

¹ Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
² Department of Pediatric Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
³ Department of Cardiology, National Center of Neurology and Psychiatry, Tokyo,Japan.

Abstract

Duchenne muscular dystrophy (DMD) is a congenital X-linked muscular dystrophy, and cardiomyopathy typically develops in the second decade of life. In those patients with severe heart failure, the use of mechanical circulatory support is considered one of the treatment options, however, the decision to implant the assist device should be made after gauging the inherent risks and potential benefits. Transcatheter mitral valve repair (TMVr) is performed in adults with heart failure due to severe mitral regurgitation (MR) refractory to guideline-directed medical therapies. Data on MitraClip-based treatment (Abbott Vascular, Menlo Park, CA, USA) of young patients with cardiomyopathy-associated severe heart failure remain limited. We present the first report on the safety and effectiveness of TMVr with the MitraClip in an 18-year-old man with DMD and severe MR who was at a prohibitive risk for mitral valve surgery or left ventricular assist device therapy due to comorbidities. He was discharged without complications and, is now asymptomatic at one year after TMVr.

Learning objective: Readers will be able to:Understand the mechanism of mitral regurgitationUnderstand the less invasiveness and usefulness of this procedure.Discuss the indication of transcatheter mitral valve repair in young patients with severe heart failure.

Keywords: Functional mitral regurgitation; Heart failure; MitraClip.

Publication types

Case Reports